P. Sung

FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase

The paper was withdrawn due to duplicate submission and is not intended for citation.

RAD51AP1 and RAD54 underpin two distinct RAD51-dependent routes of DNA damage repair via homologous recombination

This study identifies RAD51AP1 and RAD54 as two distinct RAD51-dependent HR sub-pathways, showing their combined inactivation enhances cancer cell sensitivity to DNA damage agents.

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

This study shows FMRP directly binds R-loops and inhibits DHX9 helicase activity, preventing R-loop accumulation and genome instability in FXS.

Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination

This study shows Rad55-Rad57 acts as a molecular chaperone in HR by facilitating Rad51 filament reassembly after Srs2 disruption.

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.

Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage

This study compares monomeric and dimeric forms of FAN1, showing that dimerization is required for efficient cleavage of long DNA flaps.