Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer's disease: Computational Modeling and Biological Evaluation
N. Qiu, C. Qian, T. Guo, Y. Wang, H. Jin, M. Yao, M. Li, T. Guo, Y. Lv, X. Si, S. Wu, H. Wang, X. Zhang, J. Xia
This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.
bioRxiv · Nov 3, 2023Pharmacology & Toxicology