G. Ou

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

RPRM negatively regulates ATM levels involving its phosphorylation mediated by CDK4/CDK6

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

MAK and CCRK kinases regulate kinesin-2 motility in C. elegans neuronal cilia

The paper identifies DYF-5 and DYF-18 as regulators of kinesin-2 motility in C. elegans cilia, showing they stabilize IFT particle interactions and prevent ectopic kinesin-II localization.