Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
P. Ma, J. Liu, J. Qin, L. Lai, G. S. Heo, H. Luehmann, D. Sultan, A. Bredemeyer, G. Bajpai, G. Feng, J. Jimenez, A. Parks, J. Amrute, A. Villanueva, Y. Liu, , K. Lavine
This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.
bioRxiv · Apr 28, 2023 · PreprintImmunology