P. C. Hoffmann

Nuclear pores as conduits for fluid flow during osmotic stress

This study shows that Dictyostelium discoideum uses nuclear pores as conduits for fluid flow during osmotic stress, distinct from passive diffusion and active transport.

Supramolecular architecture of the ER-mitochondria encounter structure in its native environment

The paper determines the supramolecular architecture of the ERMES complex in yeast using integrative structural biology methods, revealing its role in lipid transfer between ER and mitochondria.

The architecture of Cidec-mediated interfaces between lipid droplets

The paper visualizes lipid droplet interfaces using cryo-ET and shows lipid transfer occurs through closely apposed monolayers with exponential kinetics, suggesting a pressure-driven mechanism.

The supramolecular landscape of growing human axons

This study uses advanced imaging techniques to reveal the molecular architecture of growing human axons in cerebral organoids, highlighting structural features and functional implications.

Rod-shaped tricalbins contribute to PM asymmetry at curved ER-PM contact sites

The paper investigates how tricalbins in budding yeast regulate PM asymmetry at ER-PM contact sites through structural and genetic analyses.

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

This study investigates how Bax activity affects mitochondrial structure during apoptosis, revealing molecular and topological changes that contribute to outer membrane rupture.