MicrobiologybioRxiv
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
J. Elliott, J. E. Eschbach, P. C. Koneru…·S. B. Kutluay
This study identifies three mechanisms by which class II HIV-1 integrase substitutions disrupt IN-RNA interactions, leading to virion maturation defects and premature viral genome degradation.
DOI 10.7554/elife.54311