P. Crosby

Potassium rhythms couple the circadian clock to the cell cycle

The paper shows that circadian rhythms in intracellular potassium levels regulate the cell cycle in algae and mammalian cells.

A cellular basis for the mammalian nocturnal-diurnal switch

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1

This study shows that isoform-specific phosphorylation in the C-terminal tail of CK1δ regulates its autoinhibition and affects circadian rhythms.

CHRONO participates in multi-modal repression of circadian transcriptional complexes

This paper identifies CHRONO as a repressor of the circadian clock by modulating interactions between BMAL1 and PER2, revealing its role in fine-tuning circadian rhythmicity.

Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells

The paper identifies daily haemoglobin oxidation rhythms in red blood cells and links them to core body temperature regulation, independent of circadian mutations in nucleated cells.

Structural mimicry confers robustness in the cyanobacterial circadian clock

The paper shows SasA regulates circadian clock robustness in cyanobacteria by structurally mimicking KaiB to modulate protein complex assembly.