A. LiWang

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

Hidden conformations differentiate day and night in a circadian pacemaker

The paper uses cryo-EM to reveal structural changes in KaiC during day and night that regulate clock protein binding and circadian rhythms.

Reconstitution of an intact clock that generates circadian DNA binding in vitro

The paper reconstitutes a cyanobacterial circadian clock in vitro to study its control over gene expression and provides a platform for synthetic biology.

Structural mimicry confers robustness in the cyanobacterial circadian clock

The paper shows SasA regulates circadian clock robustness in cyanobacteria by structurally mimicking KaiB to modulate protein complex assembly.

A Novel Regulatory Role for the Circadian Clock Protein TOC1 via RNA binding

This study identifies a novel RNA-binding function for the circadian clock protein TOC1, revealing its role in regulating gene expression through RNA interactions.

Sequence-based Prediction of Metamorphic Behavior in Proteins

This paper introduces a sequence-based computational model to predict metamorphic behavior in proteins using diversity indices derived from secondary structure predictions, achieving a Matthews correlation coefficient of ~0.4.

Genome-wide fitness assessment during diurnal growth reveals an expanded role of the cyanobacterial circadian clock protein KaiA

The paper identifies genes critical for survival in light-dark cycles in cyanobacteria and shows KaiA's role in regulating a night-time metabolic program.