C. Guo

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells

This study shows that heat-killed Lactobacillus johnsonii reduces herpesvirus-induced pulmonary fibrosis in HCT mice by increasing PD-L1 on dendritic cells, which suppresses Th17 cell IL-17A.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Propofol overcome Tamoxifen resistance in breast cancer by modulating tumorogenesis, immune response and metabolism

This study shows Propofol overcomes Tamoxifen resistance in breast cancer by inducing cell cycle arrest, apoptosis, and altering gene expression related to cell cycle, immune response, and metabolism.

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

Stimulated Prorocentrum donghaiense cell growth by in-situ mariculture dissolved organic matter

This study shows that in-situ mariculture dissolved organic matter promotes growth and photosynthesis of Prorocentrum donghaiense through absorbtrophy, with bacterioplankton playing helper and competitor roles.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

Antigen-display exosomes provide adjuvant-free protection against SARS-CoV-2 disease at nanogram levels of spike protein

This study demonstrates that antigen-display exosomes can induce strong neutralizing antibodies and protect against SARS-CoV-2 at nanogram levels of spike protein without adjuvant.

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

This study compares 7 analysis pipelines and 7 experimental methods for detecting extrachromosomal circular DNA, identifying the most effective approaches for short-read and long-read sequencing data.

Adaptive immunity: from CRISPR to CRIHSP?

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

A monoclonal antibody collection for C. difficile typing

The paper develops a monoclonal antibody collection targeting C. difficile strains to improve research on clinically relevant ribotypes.

Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology

This study identifies monoclonal antibodies targeting C. difficile's S-layer protein, revealing both protective and detrimental effects on bacterial physiology.

Dietary n-3 PUFA enhances DMI in transition cows by regulating taste transduction gene expression in liver associated with rumen microbial alteration

This study shows that dietary n-3 PUFA improves dry matter intake in transition cows by altering liver gene expression related to taste transduction and modifying rumen microbial composition.

Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathy

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis

This study shows that syntenin and CD63 promote exosome biogenesis by blocking CD63 endocytosis, allowing it to accumulate at the plasma membrane where exosomes originate.

SUMOylation of MFF is required for stress-induced mitochondrial fission

The paper shows that SUMOylation of MFF at Lys151, induced by AMPK phosphorylation under stress, promotes mitochondrial fission by altering the DRP1-MiD-MFF complex.

Contribution of the IGCR1 regulatory element and the 3'Igh CBEs to Regulation of Igh V(D)J Recombination

This study investigates how IGCR1 regulatory elements and 3'Igh CBEs influence RAG-scanning and V(D)J recombination in progenitor-B cells through chromatin loop extrusion and WAPL down-regulation.

Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocin

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

Species-dependent effects of seawater acidification on alkaline phosphatase activity in dinoflagellates

This study examines how pH changes affect alkaline phosphatase activity in six dinoflagellate species, revealing species-specific responses to ocean acidification.

Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer's Amyloid-β Oligomer

The paper presents a structural model of an Alzheimer's Aβ42 oligomer based on solid-state NMR and cryo-EM data, explaining its stability and ion permeability.

De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography

The paper identifies novel sperm proteins in mammals using cryo-electron tomography and AlphaFold2 models, revealing their structural roles in flagellar mechanics.

Limitations of Busulfan to Create Humanize Mice with an Innate Immune System.

This study evaluates busulfan's effectiveness in preconditioning humanized mice for immune cell engraftment, finding it works well for hIL15-Tg-NSG but not SGM3-NSG mice.

Direct Assessment of Nitrative Stress in Lipid Environments: Applications of a Designer Lipid-Based Biosensor for Peroxynitrite

This paper develops a lipid-based biosensor to directly detect peroxynitrite in lipid environments, demonstrating its utility in live cells and lung tissue.

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis

The paper develops a viscoelastic hydrogel that promotes liver bile duct organoid growth by modulating YAP signaling and Notch activation.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

Role of Paravertebral muscle myostatin upregulation in the development of idiopathic scoliosis

This study identifies myostatin upregulation in paravertebral muscle cells as a driver of oxidative stress and apoptosis, contributing to idiopathic scoliosis development.

In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes

This study uses cryo-electron tomography to reveal the asymmetric protein complexes in mammalian sperm axonemes, explaining their unique flagellar beating pattern.

Bioprinting microporous functional living materials from protein-based core-shell microgels

This paper introduces a core-shell microgel bioprinting method to create functional living materials with controlled microporosity and enhanced bioprocessing capabilities.