c-Src induced vascular malformations require localised matrix degradation at focal adhesions
P. Essebier, L. Schimmel, T. Yordanov, M. Keyser, A. Yu, I. Noordstra, B. Hill, A. S. Yap, S. J. Stehbens, A. Lagendijk, E. Gordon
This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.
bioRxiv · Sep 15, 2023Cell Biology