S. H. Park

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.

This study identifies a novel 14-mer antiangiogenic peptide derived from prolactin that inhibits bradykinin- and eNOS-dependent angiogenesis, showing synergistic effects with Avastin in a colon cancer model.

The paper uses native mass spectrometry to analyze the oligomerization states of SARS-CoV-2 E protein, poliovirus VP4, and HIV Vpu, revealing differences in their assembly patterns.

The paper shows polyubiquitinated PCNA promotes break-induced replication at telomeres and fragile sites by recruiting SLX4, leading to telomere damage and DNA synthesis.

The paper identifies a new RiPP subclass, pimtides, by analyzing the evolutionary spread of PIMT enzymes and their role in modifying precursor peptides.

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

This study identifies distinct and coordinated roles of DacC and DacA in stress adaptation and cell shape maintenance in E. coli, independent of LD-transpeptidases and involving interactions with PBPs.

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

This study identifies PSMC family genes as prognostic indicators and therapeutic targets in lung adenocarcinoma through differential expression, methylation, mutation, and survival analysis.

This study shows that peptidoglycan carboxypeptidases in E. coli and B. subtilis affect vancomycin and β-lactam resistance independently of LD-transpeptidases, with deletion causing β-lactam sensitivity and vancomycin resistance.

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

The paper determines the cryoEM structure of the MLL1 complex bound to a nucleosome and identifies two binding modes, one of which is catalytically inactive.

This study investigates the structure of SARS-CoV-2 E protein and its interactions with amilorides, finding that binding affinity correlates with antiviral activity and that residue Asn15 is critical for maintaining the binding site conformation.

This study uses single-cell RNA sequencing to track macrophage dynamics in SARS-CoV-2-infected ferrets over time, revealing distinct subpopulations and functional changes.

This study compares 80 kVp and 80/Sn150 kVp CT in oncology patients, finding 80 kVp provides better image quality and lower radiation dose.

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

This study identifies SMAD3 as a key regulator determining conventional DC versus plasmacytoid DC differentiation through distinct gene regulatory mechanisms.

The paper develops a molecular model of the nuclear pore complex's central transporter, revealing a thermoreversible FG-network with distinct territories for different FG motifs.

The paper shows IFN-γ suppresses specific TLR4-activated genes and enhancers to enhance M1-like macrophage polarization.