R. Feederle

Structures of Arabidopsis thaliana MDL Proteins and Synergistic Effects with the Cytokine MIF on Human Receptors

A. thaliana MDLs and human MIF interact to synergistically activate CXCR2 and CXCR4 signaling.

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

This study shows that the lipid bilayer stabilizes the active site geometry of the intramembrane protease PSH, enhancing its catalytic activity compared to micelles.

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

Defining the RBPome of T helper cells to study higher order post-transcriptional gene regulation

The paper identifies the core RNA-binding protein (RBP)ome in human and mouse T helper cells, revealing new regulators of post-transcriptional gene regulation, including Celf1 as a Roquin-1-dependent coregulator of Icos.

Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43

This study identifies K136 acetylation as a key modifier of TDP-43's RNA binding and phase separation, leading to pathological aggregation, and shows SIRT1's role in deacetylating and reducing this aggregation.