Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
x. pan, f. ye, P. Ning, Z. Zhang, B. Zhang, G. Chen, W. Gao, C. Qiu, Z. Wu, K. Gong, J. Li, J. Xia, Y. Du
This study reports cryo-EM structures of HCAR2-Gi1 complexes with agonists, revealing ligand recognition, selectivity, and activation mechanisms for drug design.
bioRxiv · Mar 28, 2023Cell Biology