Author

P. Purkayastha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

K. Pendyala· 2 shared T. P. Lele· 2 shared A. Majumder· 1 shared A. S. Saxena· 1 shared B. Yu· 1 shared C. F. Baer· 1 shared D. E. Conway· 1 shared H. Hakimjavadi· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

K. Pendyala

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Author profile →

3 papers

Recent·Most cited

BioengineeringJOMPeer-reviewedJul 11, 2022

Substrate stiffness controls the cell cycle of human mesenchymal stem cells via cellular traction

S. K. Kureel, S. Sinha, P. Purkayastha…·A. Majumder

This study shows that substrate stiffness between 1 and 5 kPa acts as a mechanical switch for hMSC cell cycle regulation via contractile forces, distinct from other cell types.

DOI 10.1007/s11837-022-05392-z

humanexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivJul 6, 2022

Rho activation drives luminal collapse and eversion in epithelial acini

V. Narayanan, P. Purkayastha, B. Yu…·T. P. Lele

This study shows that RhoA activation causes apical-out eversion in epithelial acini by altering mechanical homeostasis and surface tension differences.

DOI 10.1016/j.bpj.2023.01.005

statistical modelcell signaling & trafficking

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintApr 26, 2020

Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblastspropagated on a novel soft substrate

P. Purkayastha, K. Pendyala, A. S. Saxena…·T. P. Lele

This study shows that reverse plasticity drives rapid evolution in fibroblasts adapted to soft substrates through genetic changes, not phenotypic plasticity alone.

DOI 10.1101/2020.04.26.061911

mousebulk RNA-seq

𝕏 PostBluesky