A. Majumder

Synergistic computational and experimental studies of a phosphoglycosyltransferase membrane/ligand ensemble

This study combines computational and experimental approaches to investigate the interaction of undecaprenol phosphate with the phosphoglycosyltransferase PglC from Campylobacter, revealing insights into substrate recognition and binding mechanisms.

Chromatin condensation delays human mesenchymal stem cells senescence by safeguarding nuclear damages during long-term in vitro expansion

A new competitive strategy to unveil the antibiotic-producing Actinobacteria

This paper introduces a competitive strategy to enhance antibiotic-producing Actinobacteria strain isolation by leveraging microbial interactions, resulting in strains with distinct antimicrobial properties.

Lithography-less, frugal and long-term diffusion-based static gradient generating microfluidic device for high-throughput drug testing

This paper presents a microfluidic device for drug testing that generates stable concentration gradients without requiring complex fabrication or accessories, validated with drug efficacy tests on cancer cells.

Scalable large-area mesh-structured microfluidic gradient generator for drug testing applications

This paper develops a cost-effective, scalable microfluidic gradient generator for drug testing, validated with curcumin on HeLa cells, showing comparable IC50 values to conventional methods.

Chromatin Acetylation Overrides Substrate Stiffness-Dependent Mechanoresponse and Lineage Specification in Human Mesenchymal Stem Cells

This study shows that chromatin acetylation overrides substrate stiffness effects on hMSCs phenotype and lineage specification by reprogramming mechanoresponse and fate decisions.

Extracellular Matrix protein gelatin provides higher expansion, reduces size heterogeneity, and maintains cell stiffness in a long-term culture of mesenchymal stem cells.

This study shows that gelatin-coated plates support better proliferation, reduced size heterogeneity, and maintained cell stiffness in long-term mesenchymal stem cell culture compared to other ECM proteins.

Substrate stiffness controls the cell cycle of human mesenchymal stem cells via cellular traction

This study shows that substrate stiffness between 1 and 5 kPa acts as a mechanical switch for hMSC cell cycle regulation via contractile forces, distinct from other cell types.

Adaptation in outbred sexual yeast is repeatable, polygenic, and favors rare haplotypes

This study shows that adaptation in outbred yeast is repeatable, polygenic, and driven by rare haplotypes from specific founders.

\"Viscotaxis\" - Directed Migration of Mesenchymal Stem Cells in Response to Loss Modulus Gradient

This study shows that human mesenchymal stem cells migrate from high to low loss modulus in response to viscous gradients, termed 'viscotaxis', and identifies cellular traction as the mechanism.

Asamataxis: A cooperative relayed migration in response to subsurface inhomogeneity leads to long-range self-patterning of cells

Substrate inhomogeneity and cooperative cellular traction lead to cellular migration and long-range pattern formation.

Slow and ad hoc: Unravelling the two features characterizing the development of bacterial resistance to membrane active peptides

The paper models bacterial resistance development to antimicrobial peptides, finding that lysylation slows resistance and that membrane composition reverses under drug-free conditions.

One drug multiple targets: An approach to predict drug efficacies on bacterial strains differing in membrane composition

The paper develops a model to predict daptomycin activity against Streptococcus aureus strains with varying membrane compositions, suggesting interaction with the inner membrane.

Soft Substrate Maintains Proliferative and Multi-lineage Potential of Human Mesenchymal Stem Cells on Long Term Expansion

This paper shows that culturing human mesenchymal stem cells on soft polyacrylamide gel maintains their stemness by delaying senescence compared to traditional tissue culture plates.