Cell BiologybioRxiv
SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.
DOI 10.1016/j.celrep.2023.112028