Q. Yuan

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

This study shows that Fzd6 deficiency in ciliated cells reduces pulmonary inflammation-induced cell death by increasing Akr1b8 expression and protecting against ferroptosis.

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

This study identifies LRP5 as a selective transporter for unesterified PUFAs, showing its role in mTORC1 inhibition and protection against myocardial injury.

The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study develops a method using minicircle DNA to rapidly generate CD19 CAR-T cells that are effective and safe, avoiding genomic integration risks.

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

The paper quantifies human enteric viruses in wastewater samples to assess their potential as indicators of fecal pollution and evaluates their reduction across treatment stages.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

This study evaluates 1403 FDA-approved drugs for SARS-CoV-2 inhibition using pseudovirus and authentic virus assays, identifying four compounds with potent effects and a synergistic combination.

The study links indoor microbial communities in university dormitories to asthma symptoms, finding specific taxa from different ecological niches are associated with increased or protective effects on asthma.

This study compares microbial composition in floor and air dust from university dormitories, showing significant differences that affect downstream microbiome analysis.

The paper demonstrates efficient combined nitrogen, phosphorus, and chemical oxygen demand removal in a wastewater treatment system using anaerobic-aerobic cycling and nitritation-denitritation without exogenous chemicals.