Author

P. Schuck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Organism:virus· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. Zhao· 6 shared A. Nguyen· 4 shared D. Wu· 4 shared G. Piszczek· 4 shared J. Chen· 2 shared S. Srinivasan· 2 shared Y. Li· 2 shared A. Ciling· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersBiophysics

H. Zhao

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

H. Zhao, A. M. Syed, M. M. Khalid, A. Nguyen, A. Ciling, D. Wu, W.-M. Yau, S. Srinivasan, D. Esposito, J. A. Doudna, G. Piszczek, M. Ott, P. Schuck

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

bioRxiv · Nov 22, 2023 · PreprintBiophysics

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

A. Nguyen, H. Zhao, D. Myagmarsuren, S. Srinivasan, D. Wu, J. Chen, G. Piszczek, P. Schuck

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

bioRxiv · Nov 21, 2023Biophysics

Diversity of Short Linear Interaction Motifs in SARS-CoV-2 Nucleocapsid Protein

P. Schuck, H. Zhao

The paper analyzes sequence diversity in SARS-CoV-2 nucleocapsid protein to show how viral motifs mimic host interactions and dynamically evolve.

bioRxiv · Aug 1, 2023Biophysics

An automated interface for sedimentation velocity analysis in SEDFIT

P. Schuck, S. C. To, H. Zhao

The paper introduces an automated interface for SEDFIT to enable GMP-compliant sedimentation velocity analysis and streamline large-scale data processing.

bioRxiv · May 14, 2023 · PreprintBiophysics

Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

H. Zhao, A. Nguyen, D. Wu, Y. Li, S. A. Hassan, J. Chen, H. Shroff, G. Piszczek, P. Schuck

The paper analyzes sequence and structural variability in the SARS-CoV-2 nucleocapsid protein, finding high mutability and structural plasticity linked to enhanced viral assembly efficiency.

bioRxiv · Feb 8, 2022Biophysics

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

H. Zhao, D. Wu, A. Nguyen, Y. Li, R. Adão, E. Valkov, G. H. Patterson, G. Piszczek, P. Schuck

This study investigates how SARS-CoV-2 N-protein interacts with nucleic acids to form supramolecular clusters and phase-separated droplets, revealing structural and energetic changes during assembly.

bioRxiv · Feb 8, 2021Biophysics