P. Sengupta

Host ZCCHC3 blocks HIV-1 infection and production by a dual mechanism

This study identifies ZCCHC3 as a novel anti-HIV-1 factor that acts through a dual mechanism to block viral infection and production.

xbx-4, a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and MAK kinase cascade to regulate cilia morphology

This study identifies XBX-4 as a regulator of the CCRK/MAK kinase pathway in C. elegans, showing it controls cilia morphology and that mutations in its DUF3719 domain cause ciliary elongation.

Vacuole phase-partitioning boosts mitochondria activity and cell lifespan through an inter-organelle lipid pipeline

The paper identifies a lipid trafficking pathway between yeast vacuoles and mitochondria that enhances mitochondrial activity and cell lifespan under glucose starvation.

A fungal member of the microbial phyllosphere antagonizes infection of Arabidopsis thaliana by the oomycete pathogen Albugo laibachii via a secreted lysozyme

The paper identifies a fungal lysozyme that reduces infection of Arabidopsis by an oomycete pathogen through microbial antagonism in the phyllosphere.

Nanoencapsulation of clove oil and study of physico-chemical properties, cytotoxic, haemolytic and antioxidant activities

This paper nanoencapsulates clove oil using maltodextrin and surfactants to improve stability and bioactivity, showing reduced cytotoxicity and enhanced antioxidant activity.

ER membranes exhibit phase behavior at sites of organelle contact

The paper demonstrates that ER membranes can phase separate into liquid-ordered and liquid-disordered domains using Large Intra-Cellular Vesicles generated by hypotonic treatment.

The C. elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

This study identifies TUB-1 as a regulator of cilia membrane morphogenesis and phospholipid composition in C. elegans, linking it to sensory signaling and structural plasticity.

Optical excitation and detection of neuronal activity

This paper demonstrates phase imaging as a label-free method to detect optogenetic-induced intracellular transport in neurons.

Immature HIV-1 Lattice Assembly Dynamics are Regulated by Scaffolding from Nucleic Acid and the Plasma Membrane

This study investigates how HIV-1 Gag polyprotein assembly is regulated by RNA and the plasma membrane using computational and experimental methods, revealing scaffolding roles for these components.