M. Yeager

Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model

This paper shows that m-tirofiban, a non-partial agonist of IIbβ3, effectively inhibits venous thrombosis without increasing bleeding in a mouse model.

CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

Inositol hexakisphosphate (IP6) accelerates immature HIV-1 Gag protein assembly towards kinetically-trapped morphologies

This study uses simulations to show IP6 accelerates HIV-1 Gag assembly, promoting curvature and defects that may aid viral morphogenesis.

Extrachromosomal Amplification of Human Papillomavirus Episomes as a Mechanism of Cervical Carcinogenesis

The paper identifies extrachromosomal HPV16 episomes as a mechanism of cervical carcinogenesis, showing that they can cause cancer without integration through rearranged and multimer episomes.

Preservation of HIV-1 Gag helical bundle symmetry by bevirimat is central tomaturation inhibition

This study uses molecular dynamics simulations to show that bevirimat's effectiveness against HIV-1 depends on preserving the six-helix bundle symmetry, with escape mutations causing symmetry loss.

A Constitutively Closed Pannexin1 Channel in Lipid Bilayer Nanodiscs Assembles as a Large-Pore Heptamer

The paper examines a constitutively closed Panx1 channel, showing it assembles as a heptamer in solution and by cryoEM, with structural insights into large-pore channels.

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

This paper examines the genetic structure and adaptation of Andean highlanders and Amazonian dwellers, showing how geography and culture influence genetic differentiation and natural selection.

Human papillomavirus 16 positive cervical cancer in Guatemala: The D2 and D3 sublineages differ in integration rate and age of diagnosis

This study compares HPV16 D2 and D3 sublineages in Guatemalan cervical cancer samples, finding differences in integration rates, age of diagnosis, and somatic mutation frequency.

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

The paper uses MicroED to determine the structure of HIV-1 Gag CTD-SP1 with bevirimat, revealing binding interactions that inform drug discovery.

Immature HIV-1 Lattice Assembly Dynamics are Regulated by Scaffolding from Nucleic Acid and the Plasma Membrane

This study investigates how HIV-1 Gag polyprotein assembly is regulated by RNA and the plasma membrane using computational and experimental methods, revealing scaffolding roles for these components.

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery

This study identifies three colorectal cancer risk loci associated with poor prognosis in rectal cancer patients and links some SNPs to chemoradiotherapy resistance.