Cancer BiologybioRxiv
XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
T. Zou, M. Zhou, A. Gupta…·M. Meyerson
The paper shows that deleting XRN1 activates PKR and kills cancer cells with high interferon expression, suggesting XRN1 as a therapeutic target.
DOI 10.1016/j.celrep.2023.113600