Author

M. Westberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

L. Ning· 3 shared M. Lin· 3 shared Y. Su· 3 shared D. Fernandez· 2 shared M. Z. Lin· 2 shared X. Zou· 2 shared Y. Wu· 2 shared A. Beck· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersMicrobiology

L. Ning

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Photoswitchable binders enable temporal dissection of endogenous protein function

M. Westberg, D. Song, V. Duong, D. Fernandez, P.-S. Huang, M. Z. Lin

This paper introduces photoswitchable DARPins (psDARPins) for optical control of endogenous protein function, demonstrating their use in inhibiting ERK and Ras and studying EGFR to ERK signaling.

bioRxiv · Sep 14, 2023 · PreprintBiochemistry

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

M. Westberg, Y. Su, X. Zou, P. Huang, A. Rustagi, J. Garhyan, P. B. Patel, D. Fernandez, Y. Wu, L. Ning, A. Beck, M. Karim, C. Hao, P. Saenkham-Huntsinger, V. Tat, , M. Z. Lin

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

Y. Wu, J. Walker, L. Ning, M. Westberg, M. Monje, T. Kirkland, M. Lin, Y. Su

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

bioRxiv · Dec 30, 2022Pharmacology & Toxicology

A red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3

B. B. Kim, H. Wu, Y. A. Hao, M. Pan, M. Chavarha, M. Westberg, F. St-Pierre, J. C. Wu, M. Lin

The paper develops a ratiometric voltage indicator by fusing an improved red fluorescent protein to ASAP3, enabling motion artifact-free voltage imaging in motile cells.

bioRxiv · Oct 9, 2020Cell Biology

Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases

M. Westberg, Y. Su, X. Zou, L. Ning, B. Hurst, B. Tarbet, M. Lin

The paper designs a new class of protease inhibitors targeting coronavirus Mpro, identifying ML1000 as a potent inhibitor with low-nanomolar affinity and antiviral activity.

bioRxiv · Sep 15, 2020Biochemistry