N. Mehta

The olfactory receptor SNIF-1 mediates foraging for leucine-rich diets in Caenorhabditis elegans

This study identifies SNIF-1 as an olfactory receptor in C. elegans that mediates foraging for leucine-rich diets via the AWC neurons in response to isoamyl alcohol.

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes

The paper identifies biosynthetic pathways for eukaryotic toxins in daffodils by showing that toxin production is localized to growing tissues.

Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

The paper uses spatially aware deep learning to identify tumor heterogeneity patterns in kidney cancer, revealing distinct states associated with different histological subtypes.

Description of Gloeomargarita ahousahtiae sp. nov., a thermophilic member of the order Gloeomargaritales with intracellular carbonate inclusions

This paper describes a new thermophilic cyanobacterium, Gloeomargarita ahousahtiae, isolated from a hot spring, characterized by intracellular carbonate inclusions and distinct phenotypic features.

Syntaxin 3-SPI 2 dependent cross-talk facilitates the division of Salmonella containing vacuole (SCV)

This study shows that Syntaxin 3 interacts with Salmonella containing vacuoles (SCVs) via SPI-2 encoded T3SS, facilitating SCV division and bacterial replication in macrophages.

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells

This study identifies Zfp335 as a transcription factor that regulates survival of post-β-selection DN4 thymocytes by suppressing cGAS/STING-dependent apoptosis.

Examining Batch Effect in Histopathology as a Distributionally Robust Optimization Problem

This paper shows that using abstention in a patch-based classifier improves performance in histopathology tasks while reducing reliance on spurious features.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

Deciphering the differential physiological and molecular requirements for conidial anastomosis tube fusion and germ tube formation in Colletotrichum gloeosporioides.

This study identifies the physiological and molecular differences between germ tube and conidial anastomosis tube formation in C. gloeosporioides, revealing distinct gene expression patterns and functional pathways.

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

Multimodal Label-free Monitoring of Adipogenic Stem Cell Differentiation using Endogenous Optical Biomarkers

This study uses multimodal imaging techniques to label-free identify adipogenic stem cell differentiation with high resolution.

Protein tyrosine phosphatase-PEST (PTP-PEST) mediates hypoxia-induced endothelial autophagy and angiogenesis through AMPK activation

This study shows that PTP-PEST promotes hypoxia-induced endothelial autophagy and angiogenesis by activating AMPK.

Structure and Functional Binding Epitope of V-domain Ig Suppressor of T-cell Activation (VISTA)

This study determines the crystal structure of human VISTA and identifies its binding epitope for an anti-VISTA antibody and VSIG3.