R. A. Beckman

The paper develops two in vitro models of endocrine therapy-resistant HER2+/ER+ breast cancer and identifies lipid metabolism and ferroptosis as therapeutic vulnerabilities.

This paper evaluates a randomized basket trial design that controls false positive rate by indication, showing improved efficiency compared to parallel studies.

This study quantifies subclonal mutations in colorectal cancer using Duplex Sequencing, revealing high mutation rates and confirming neutral evolution in tumors.

This study models bistable tumour population dynamics to evaluate treatment strategies, finding that periodic treatments outperform static ones and optimal control theory-based treatments are most effective.