Author

R. Abel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

J. D. Chodera· 2 shared L. Wang· 2 shared S. K. Albanese· 2 shared A. Gruber· 1 shared A. Schroeder· 1 shared A. Volkamer· 1 shared B. A. Horwitz· 1 shared C. Negron· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

J. D. Chodera

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Author profile →

4 papers

Recent·Most cited

Runaway resorption of microcracks contributes to age-related hip-fracture patients

M. Gray, O. Boughton, C. Wiles, C. Reinhard, N. T. Vo, R. Atwood, R. Stavri, J. Cobb, U. Hansen, R. Abel

The paper investigates microdefects in hip-fracture patients and finds they are more prevalent and negatively correlate with bone strength.

bioRxiv · Jun 9, 2024Bioengineering

Bioluminescent Synthetic Cells Communicate with Natural Cells and Self-Activate Light-Responsive Proteins

O. Adir, R. Abel, M. R. Albalak, L. E. Weiss, G. Chen, A. Gruber, O. Staufer, J. Shklover, J. Shainsky-Roitman, I. Platzman, L. Gepstein, Y. Shechtman, B. A. Horwitz, A. Schroeder

This paper develops bioluminescent synthetic cells that communicate with natural cells and self-activate light-responsive proteins, enabling in vivo applications without external light sources.

bioRxiv · May 20, 2021 · PreprintBioengineering

Is structure based drug design ready for selectivity optimization?

S. K. Albanese, J. D. Chodera, A. Volkamer, S. Keng, R. Abel, L. Wang

This study evaluates the accuracy of predicting compound selectivity using free energy calculations for kinase inhibitors, finding that systematic errors correlate between targets and longer simulations improve selectivity prediction.

bioRxiv · Jul 2, 2020Biophysics

Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations

K. Hauser, C. Negron, S. K. Albanese, S. Ray, T. Steinbrecher, R. Abel, J. D. Chodera, L. Wang

This paper uses alchemical free-energy calculations to predict how Abl mutations affect inhibitor affinity, achieving accurate results for clinical mutations.

bioRxiv · Apr 2, 2018Cancer Biology