Author

K. Hauser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metagenomics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. D. Chodera· 2 shared A. Cornacchia· 1 shared A. Ghez Farrell· 1 shared A. J. Greaney· 1 shared A. N. Loes· 1 shared B. Dadonaite· 1 shared C. Janson· 1 shared C. Lam· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

J. D. Chodera

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Author profile →

5 papers

Recent·Most cited

Identifying and overcoming the sampling challenges in relative binding free energy calculations of a model protein:protein complex

I. Zhang, D. A. Rufa, I. Pulido, M. M. Henry, L. E. Rosen, K. Hauser, S. Singh, J. D. Chodera

This study identifies sampling challenges in protein:protein binding free energy calculations and demonstrates how to overcome them using alchemical methods and long simulations.

bioRxiv · Mar 7, 2023Biophysics

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

T. N. Starr, A. J. Greaney, W. W. Hannon, A. N. Loes, K. Hauser, J. R. Dillen, E. Ferri, A. Ghez Farrell, B. Dadonaite, M. McCallum, K. A. Matreyek, D. Corti, D. Veesler, G. Snell, J. D. Bloom

The paper analyzes epistatic shifts in SARS-CoV-2 RBD mutations across variants to understand how they influence ACE2 binding and future evolution.

bioRxiv · Feb 24, 2022Microbiology

High prevalence of Klebsiella pneumoniae in European food products: a multicentric study comparing culture and molecular detection methods

C. Rodrigues, K. Hauser, N. Cahill, M. Ligowska-Marzeta, G. Centorotola, A. Cornacchia, R. Garcia Fierro, M. Haenni, E. Moller Nielsen, P. Piveteau, E. Barbier, D. Morris, F. Pomilio, S. Brisse

The paper identifies high prevalence of Klebsiella pneumoniae in European chicken meat and salad samples using culture and molecular methods, revealing genetic diversity and potential transmission within the food sector.

bioRxiv · Nov 24, 2021Microbiology

Energy-dependent transport at dural lymphatic vessels is necessary for Aβ brain clearance in Alzheimer's disease

L. Romanova, H. Philips, G. Calip, K. Hauser, D. Peterson, O. Lazarov, D. Predescu, S. Predescu, J. Schneider, J. Kordower, E. Hansen, C. Lam, C. Janson

The paper shows that energy-dependent transport in dural lymphatic vessels is critical for clearing Aβ in Alzheimer's disease, and blocking this pathway accelerates Aβ pathology.

bioRxiv · Feb 5, 2019 · PreprintBiochemistry

Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations

K. Hauser, C. Negron, S. K. Albanese, S. Ray, T. Steinbrecher, R. Abel, J. D. Chodera, L. Wang

This paper uses alchemical free-energy calculations to predict how Abl mutations affect inhibitor affinity, achieving accurate results for clinical mutations.

bioRxiv · Apr 2, 2018Cancer Biology