Author

R. Chambers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Plate· 2 shared A. Blanchard· 1 shared A. Fisher· 1 shared A. Taylor· 1 shared D. Clements· 1 shared D. Guillotin· 1 shared E. L. Rawlins· 1 shared G. Miele· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

M. Plate

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2 papers

Recent·Most cited

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

R. Babaei-Jadidi, D. Clements, Y. Wu, K. Chen, S. Miller, M. Plate, K. Lim, R. Chambers, E. L. Rawlins, Y. Xu, S. R. Johnson

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

bioRxiv · May 3, 2024 · PreprintCell Biology

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

D. Guillotin, A. Taylor, M. Plate, P. Mercer, L. Edwards, R. Haggart, G. Miele, R. McAnulty, T. Maher, R. E. Hynds, M. Jamal-Hanjani, R. Marshall, A. Fisher, A. Blanchard, R. Chambers

This study identifies key transcriptional pathways in IPF fibroblastic foci using RNA-seq and bioinformatics, highlighting the TSC2/RHEB axis as a potential therapeutic target for fibrosis.

bioRxiv · Mar 10, 2020Cell Biology