mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis
R. Babaei-Jadidi, D. Clements, Y. Wu, K. Chen, S. Miller, M. Plate, K. Lim, R. Chambers, E. L. Rawlins, Y. Xu, S. R. Johnson
This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.
bioRxiv · May 3, 2024 · PreprintCell Biology