PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
F. Wiede, K.-H. Lu, X. Du, M. Zessig, R. Xu, P. K. Goh, C. Xirouchaki, S. Hogarth, S. Greatorex, K. Sek, R. Daly, P. Beavis, P. Darcy, N. Tonks, T. Tiganis
This study identifies PTP1B as an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity, showing its deletion or inhibition enhances tumor suppression.
bioRxiv · Nov 11, 2021Cancer Biology