Author

V. Tillu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. G. Parton· 4 shared B. Collins· 3 shared J. Rae· 3 shared M. Bastiani· 3 shared N. Ariotti· 3 shared A. S. Yap· 2 shared B. M. Collins· 2 shared D. A. Stroud· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCell Biology

R. G. Parton

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resistance

J. W. Brooks, V. Tillu, S. Verma, B. M. Collins, R. G. Parton, A. S. Yap

The paper shows that caveola disassembly under mechanical stress reinforces the actin cortex at adherens junctions, enhancing epithelial resistance to tensile stress.

bioRxiv · Mar 29, 2023Cell Biology

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

M. D. Healy, J. Sacharz, K. E. McNally, C. McConville, V. Tillu, R. J. Hall, M. Chilton, P. J. Cullen, M. Mobli, R. Ghai, D. A. Stroud, B. Collins

The paper identifies the structural basis of the interaction between SNX17 and PDLIM family proteins, revealing a specific PDZ binding motif and unique electrostatic contacts.

bioRxiv · Jul 29, 2021Biochemistry

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

V. Tillu, J. Rae, Y. Gao, N. Ariotti, M. Floetenmeyer, O. Kovtun, K.-A. McMahon, N. Chaudhary, R. G. Parton, B. M. Collins

This study shows that Cavin1's intrinsically disordered domains are essential for caveola formation and trafficking through electrostatic interactions and phase separation.

Nature Communications · Feb 10, 2021Peer-reviewedCell Biology

Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

H. Lo, Y.-W. Lim, Z. Xiong, N. Martel, C. Ferguson, N. Ariotti, J. Giacomotto, J. Rae, M. Floetenmeyer, S. V. Moradi, Y. Gao, V. Tillu, D. Xia, H. Wang, S. Rahnama, , R. Parton

This study identifies Cavin4's role in T-tubule formation and stability in skeletal muscle by showing its interaction with Bin1 and effects on caveolae remodeling.

bioRxiv · Jan 13, 2021Cell Biology

Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

R. G. Parton, K.-A. McMahon, D. A. Stroud, Y. Gambin, V. Tillu, M. Bastiani, E. Sierecki, M. Polinkovsky, T. E. Hall, G. A. Gomez, Y. Wu, M.-O. Parat, N. Martel, H. P. Lo, K. k. Khanna, , M. Ryan

This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.

bioRxiv · Jul 26, 2020Cancer Biology

Dissecting the nanoscale lipid profile of caveolae

Y. Zhou, N. Ariotti, J. Rae, H. Liang, V. Tillu, S. Tee, M. Bastiani, A. T. Bademosi, B. Collins, F. A. Meunier, J. F. Hancock, R. G. Parton

This study defines the caveolar lipid profile using quantitative lipid mapping and simulations, showing how CAV1 and cavin1 sort distinct lipids and create a unique lipid environment.

bioRxiv · Jan 16, 2020Biochemistry