Cancer BiologybioRxivPreprint
Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis
B. Ngo, E. Kim, V. Osorio-Vasquez…·M. E. Pacold
This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.
DOI 10.1101/2020.03.03.974980