Author

A. Luengo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

M. G. Vander Heiden· 3 shared A. Ali· 2 shared A. Friedman· 1 shared A. N. Lau· 1 shared A. Naamati· 1 shared A. Plasger· 1 shared B. Grauman-Boss· 1 shared B. Ngo· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

M. G. Vander Heiden

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3 papers

Recent·Most cited

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

A. Luengo, Z. Li, D. Y. Gui, L. B. Sullivan, M. Zagorulya, B. T. Do, R. Ferriera, A. Naamati, A. Ali, C. A. Lewis, C. J. Thomas, S. Spranger, N. J. Matheson, M. G. Vander Heiden

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

bioRxiv · Jun 8, 2020Biochemistry

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

bioRxiv · Mar 3, 2020 · PreprintCancer Biology

Pancreatic Stellate Cells Secrete Deoxycytidine Conferring Resistance to Gemcitabine in PDAC

S. Dalin, M. R. Sullivan, E. Kreidl, A. N. Lau, B. Grauman-Boss, S. Fenoglio, A. Luengo, M. G. Vander Heiden, D. A. Lauffenburger, M. T. Hemann

This study shows that pancreatic stellate cells secrete deoxycytidine, which reduces the effectiveness of gemcitabine in PDAC by inhibiting its processing in cancer cells.

Cancer Research · Nov 15, 2019Peer-reviewedCancer Biology