R. F. Thompson

This study identifies higher-order structures of the foot-and-mouth disease virus RdRp and their role in RNA replication through cryo-EM and mutagenesis.

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

This study examines how different macromolecular complexes behave during cryoEM grid preparation at various timescales using three vitrification devices.

This study evaluates tumor mutational burden (TMB) and related metrics as predictors of immunotherapy response and survival, finding limited predictive value in some cancers and instability in its use.

The paper analyzes RNA-seq data to show that many cancer-specific splicing events are also present in non-cancer tissues and developmental cells, suggesting they may not be unique to cancer.

The paper introduces four metrics to prioritize neoepitopes based on peptide novelty and evaluates their immunogenicity using TCGA and melanoma patient data.