M. Pal

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-IP7

The paper shows that IP6K1 interacts with proteins that undergo pyrophosphorylation and with CK2, enabling coordinated pre-phosphorylation and pyrophosphorylation of target serine residues.

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

This study shows that deleting TFAP4 in E-MYC transgenic mice accelerates lymphoma development by blocking B cell differentiation.

Analytical Comparability to Evaluate Impact of Manufacturing Changes of ARX788, an Anti-HER2 ADC in Late-Stage Clinical Development

The paper evaluates the impact of manufacturing changes on ARX788, an anti-HER2 ADC, using ICH Q5E guidelines and shows no adverse effect on product quality.

Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres

The paper identifies a third example of convergent evolution where the TRF2 iDDR motif binds human RAD50 at the same site as the yeast MIN motif, inhibiting MRN nuclease activity at telomeres.

Preclinical efficacy of bacosides-lauric acid nano-herbal formulation incomparison to rivastigmine for treatment of Alzheimer's disease

This study evaluates a nano-herbal formulation of bacosides-lauric acid in preclinical models of Alzheimer's disease, showing reduced amyloid burden, neuroprotection, anti-inflammatory effects, and improved cognition compared to rivastigmine.

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

Allee dynamics: growth, extinction and range expansion

The paper studies a reaction-diffusion model incorporating Allee effects, showing extinction and range expansion dynamics in budding yeast populations.

Criticality in Cell Differentiation

This paper reviews the concept of criticality in cell differentiation, linking theoretical models to experimental observations in mouse blood cell differentiation.