Author

E. Mugarza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2

Frequent Co-Authors

C. Moore· 6 shared J. Downward· 6 shared S. Rana· 6 shared M. Molina-Arcas· 5 shared J. Boumelha· 4 shared P. Anastasiou· 4 shared C. Swanton· 3 shared F. van Maldegem· 3 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCancer Biology

C. Moore

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6 papers

Recent·Most cited

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

M. Cole, P. Anastasiou, C. Lee, C. Moore, E. Mugarza, M. Jones, K. Valand, S. Rana, E. Colliver, M. Angelova, K. Enfield, A. Magness, A. Mullokandov, G. Kelly, T. de Gruijl, , F. van Maldegem

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

bioRxiv · Apr 11, 2024Cancer Biology

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

P. Anastasiou, C. Moore, S. Rana, A. de Castro, M. Tomaschko, J. Boumelha, E. Mugarza, C. Blaj, S. de Carne Trecesson, R. Goldstone, J. Smith, E. Quintana, M. Molina-Arcas, J. Downward

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

bioRxiv · Jan 15, 2024Cancer Biology

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

J. Boumelha, A. de Castro, N. Bah, H. Cha, S. de Carne Trecesson, S. Rana, P. Anastasiou, E. Mugarza, C. Moore, R. Goldstone, P. East, K. Litchfield, S.-H. Lee, M. Molina-Arcas, J. Downward

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

bioRxiv · Apr 13, 2023Cancer Biology

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. L. Sopena, P. East, R. Ambler, P. Anastasiou, P. R. Clavijo, K. Valand, M. Cole, M. Molina-Arcas, J. Downward

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

bioRxiv · Oct 18, 2021Cancer Biology

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

F. van Maldegem, K. Valand, M. Cole, H. Patel, M. Angelova, S. Rana, E. Colliver, K. Enfield, N. Bah, V. Tsang, E. Mugarza, C. Moore, P. Hobson, D. Levi, M. Molina, , J. Downward

The paper optimises an imaging mass cytometry workflow to study TME remodelling in mouse models after KRAS G12C inhibitor treatment.

bioRxiv · Feb 2, 2021Cancer Biology

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

J. Boumelha, S. de Carne Trecesson, E. Law, P. Romero-Clavijo, M. Coelho, K. Ng, E. Mugarza, C. Moore, S. Rana, D. Caswell, M. Murillo, D. Hancock, P. Argyris, W. Brown, C. Durfee, , J. Downward

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

bioRxiv · Dec 22, 2020Cancer Biology