R. Gonzalez

Experimental evolution of an RNA virus in Caenorhabditis elegans

This study evolves two Orsay virus strains in C. elegans, finding slight infectivity changes, non-synonymous mutations, and non-random distribution of minor variants in polymorphic regions.

Within-host virus spreading and tolerance to infection are key factors of the Arabidopsis thaliana age-dependent susceptibility to viral infections

This study investigates age-dependent susceptibility to viral infections in Arabidopsis thaliana, finding that later stages show increased viral spread but also greater fertility, suggesting a trade-off between susceptibility and fitness.

Natural monobacterial environments modulate viral infection in Caenorhabditis elegans

This study investigates how natural bacterial environments affect Caenorhabditis elegans susceptibility to Orsay virus, finding that most bacteria reduce infection while some increase it, independent of antiviral mechanisms.

Host age-dependent evolution of a plant RNA virus

This study investigates how host age affects virus evolution in plants, finding that older hosts lead to faster and more severe infections, with genomic changes varying by host age and viral isolate.

Deep neural network models reveal interplay of peripheral coding and stimulus statistics in pitch perception

This study uses deep neural networks to show that pitch perception is influenced by both cochlear properties and natural sound statistics.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

Arabidopsis thaliana genes contributing to differences in the outcome of infection with generalist and specialist strains of Turnip mosaic virus identified by genome-wide association studies

This study identifies Arabidopsis thaliana genes associated with infection outcomes by generalist and specialist Turnip mosaic virus strains using GWAS.

Defects in plant immunity modulate the rates and patterns of RNA virus evolution

This study shows that host immunity differences affect RNA virus evolution rates and patterns, with resistant hosts driving faster adaptation and permissive hosts selecting for specialist viruses.

Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique

The paper measures antibody transfer from HIV-infected mothers to infants in Mozambique and finds HIV reduces placental transfer of IgG and IgG1 antibodies against pathogens and vaccine antigens.

Revisiting Orthotospovirus Phylogeny Using Whole Genomic Data and a Hypothesis for their Geographic Origin and Diversification

This study uses complete genomic data from 20 Orthotospovirus species to revise their phylogeny, identify four phylogroups, and estimate divergence times and geographic origin.

Quantification of malaria antigens PfHRP2 and pLDH by quantitative suspension array technology in whole blood, dried blood spot and plasma

This paper develops and validates a quantitative suspension array technology to measure malaria antigens PfHRP2 and pLDH in various clinical samples, showing strong correlation with parasite density.

Role of host genetic diversity for susceptibility-to-infection in the evolution of virulence of a plant virus

This study shows that host genetic diversity influences the evolution of virulence in Turnip mosaic virus, with more pathogenic viruses evolving in genetically heterogeneous host populations.

Land-use and related pressures have reduced biotic integrity more on islands than on mainlands

The paper updates the Biodiversity Intactness Index (BII) to assess biotic integrity changes on islands versus mainlands, finding that islands have experienced greater declines in richness-based BII due to human pressures.

Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers

This paper demonstrates that pancreatic tumor organoids (PDOs) recapitulate PDX models' features and can identify clinically-actionable biomarkers in blood.