E. Young

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

The Pathfinder plasmid toolkit for genetically engineering newly isolated bacteria enables the study of Drosophila-colonizing Orbaceae

The paper introduces the Pathfinder plasmid toolkit to test genetic part compatibility in newly isolated bacteria, demonstrating its use in engineering Orbaceae strains to study their colonization of Drosophila gut.

Pinning transition in biofilm structure driven by active layer dynamics

This study uses simulations to show how active layer dynamics in biofilms lead to different structural phases, with pinning transitions affecting interface roughness and morphology.

Defining levels of dengue virus serotype-specific neutralizing antibodies induced by a live attenuated tetravalent dengue vaccine (TAK-003)

This study characterizes the serotype-specific neutralizing antibody responses induced by the tetravalent dengue vaccine TAK-003 in humans and non-human primates, finding that DENV2 is immunodominant while DENV1, 3, and 4 responses are lower and cross-reactive.

Disease Risk Analysis in sea turtles: A baseline study to inform conservation efforts

This study conducts a disease risk analysis for all seven sea turtle species, identifying knowledge gaps and suggesting management strategies for conservation.

STAT5: A Target of Antagonism by Neurotropic Flaviviruses

The paper identifies STAT5 as a target of antagonism by WNV and ZIKV in human DCs, showing differential inhibition of Jak kinases compared to other flaviviruses.

Dynamics of the p53 response to ionizing and ultraviolet radiation

This paper proposes a mathematical model explaining how p53 exhibits distinct dynamic responses to ionizing and ultraviolet radiation, with implications for cell fate decisions.