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Primary ORCID profile (0009-0004-0002-355X · 5 papers)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
C. H. Arrowsmith, S. Ackloo, F. Li, M. Szewczyk, A. Seitova, P. Loppnau, H. Zeng, S. Ahmad, S. Beldar, A. Bolotokova, I. Chau, S. Dehghani-Tafti, A. Dong, P. Ghiabi, E. Gibson, , Arnautova
The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.
bioRxiv · Mar 3, 2024Biochemistry
G. L. Righetto, Y. Yin, V. Vu, D. Duda, M. Szewczyk, H. Zeng, Y. Li, P. Loppnau, T. Mei, Y.-Y. Li, A. Seitova, J.-F. Brazeau, D. Barsyte-Lovejoy, V. Santhakumar, C. Chaudhry, L. Halabelian
This study characterizes DCAF12 interactions with MAGEA3 and CCT5 degrons using biophysical assays and cryo-EM, revealing key residues for degron recognition and informing PROTAC design.
bioRxiv · Aug 15, 2023 · PreprintBiochemistry
M. G. Alteen, J. C. Deme, C. P. Alvarez, P. Loppnau, A. Hutchinson, A. Seitova, R. Chandrasekaran, E. Silva Ramos, C. Secker, M. Alqazzaz, E. E. Wanker, S. M. Lea, C. H. Arrowsmith, R. J. Harding
This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.
bioRxiv · Nov 21, 2022Biochemistry
R. J. Harding, J. C. Deme, J. F. Hevler, S. Tamara, A. Lemak, J. P. Cantle, M. M. Szewczyk, X. Zuo, P. Loppnau, A. Seitova, A. Hutchinson, L. Fan, M. Schapira, J. B. Carroll, A. J. R. Heck, , C. H. Arrowsmith
This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.
bioRxiv · Apr 2, 2021Biochemistry
K. Devkota, M. Schapira, S. Perveen, A. Khalili Yazdi, F. Li, I. Chau, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, K. J. Satchell, K. Wang, D. Li, J. Liu, D. Smil, , M. Vedadi
This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.
bioRxiv · Feb 19, 2021Biochemistry
S. Perveen, A. Khalili Yazdi, K. Devkota, F. Li, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, M. Vedadi
The paper develops a fluorescence polarization assay for screening RNA-competitive inhibitors of the SARS-CoV-2 nsp10-nsp16 complex, validated with 1124 compounds.
bioRxiv · Oct 14, 2020Biochemistry
h. zhang, M. Devoucoux, l. li, G. Ayaz, h. cheng, W. Tempel, c. dong, P. Loppnau, J. Cote, j. min, x. song
The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.
bioRxiv · Mar 24, 2020Biochemistry
R. J. Harding, P. Loppnau, S. Ackloo, A. Lemak, A. Hutchinson, B. Hunt, A. Holehouse, J. Ho, L. Fan, L. Toledo-Sherman, A. Seitova, C. Arrowsmith
This paper develops a toolkit for producing mutant and wild-type huntingtin proteins in eukaryotic systems to enable biochemical and structural studies of HD-related mutations.
bioRxiv · Feb 5, 2019Biochemistry
Y. Zhang, M. Lei, X. Liang, P. Loppnau, Y. Li, J. Min, Y. Liu
The paper investigates the interaction between the TIP60 chromo barrel domain and histone peptides, finding no binding observed through fluorescence polarization or isothermal titration calorimetry and presenting a crystal structure of the domain.
bioRxiv · Jan 31, 2018Biochemistry
M. Lei, Y. Feng, M. Zhou, Y. Yang, P. Loppnau, Y. Li, Y. Yang, Y. Liu
The paper reports the crystal structure of RBBP1's chromo barrel domain and shows it does not bind DNA, contradicting previous reports of DNA-enhanced histone binding.
bioRxiv · Jan 31, 2018Biochemistry