L. King

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens

The paper analyzes the virome of agricultural slurry using hybrid sequencing, revealing a diverse and stable community with potential to influence bacterial metabolism and virulence.

BioID based proteomic analysis of the Bid interactome identifies novel proteins involved in cell cycle dependent apoptotic priming.

The paper uses BioID to identify novel Bid interactors involved in cell cycle-dependent apoptotic priming, highlighting VDAC2's role in Bid phosphorylation and sensitivity to anti-mitotic drugs.

Unmasking the tissue microecology of ductal carcinoma in situ with deep learning

This paper develops a deep learning pipeline to detect and segment DCIS ducts, revealing that pure DCIS has more TILs but less co-localization with ducts compared to adjacent DCIS.

Bax mitochondrial residency is more critical than Bax oligomerization for apoptosis

This study shows that Bax mitochondrial residency, not oligomerization, is critical for apoptosis, using mutants in cell-free and cellular systems.

Phylogenomics, biogeography, and evolution in the American palm genus Brahea

This study uses genome-scale data to infer phylogenetic relationships, ancestral growth forms, and biogeographic history in the American palm genus Brahea.