ImmunologybioRxivPreprint
Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response
L. P. Deimel, X. Xue, A. Khan…·Q. J. Sattentau
This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.
DOI 10.1101/2023.06.03.543556