G. Rao

The impact of transplant location on the gut microbiome and resistome in patients undergoing hematopoietic stem cell transplantation at home versus in the hospital

This study compares the gut microbiome and resistome of patients undergoing home versus hospital hematopoietic stem cell transplantation, finding no significant differences but noting confounding factors in secondary analyses.

Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

Remote neuronal activity drives glioma infiltration via Sema4f

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor

This study identifies a Mn/Fe cofactor-dependent enzyme that hydroxylates a highly stable C-H bond, revealing a novel mechanism for Mn-dependent monooxygenase activity.

An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics

This paper describes a cell-free biomanufacturing approach for rapid production of griffithsin, a broad-spectrum antiviral protein, demonstrating its efficacy against SARS-CoV-2 and HIV-1.

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

Identification of functional immune and neuronal tumor cells in glioma

The paper introduces SCRAM, a tool that identifies tumor-specific cell types in glioma with functional properties similar to non-tumor cells.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

Decreased investigatory head scanning during exploration in learning-impaired, aged rats

This study examines head scanning behavior in aged rats with and without spatial learning impairments, finding that aged-impaired rats show reduced head scanning rates compared to young rats.

Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

This study identifies three molecular types of meningiomas that better predict recurrence than WHO grading and links aggressive tumors to loss of DREAM complex repression.

Can individual and integrated water, sanitation, and handwashing interventions reduce fecal contamination in the household environment? Evidence from the WASH Benefits cluster-randomized trial in rural Kenya

This study evaluates the effectiveness of water, sanitation, and handwashing interventions in reducing fecal contamination in rural Kenyan households, finding limited success in reducing E. coli on child hands and toys.

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.