R. Vasan

Colony context and size-dependent compensation mechanisms give rise to variations in nuclear growth trajectories

The paper analyzes nuclear growth variations in hiPS cell colonies, finding context-dependent and inherited mechanisms shaping growth trajectories.

Actin force generation in vesicle formation: mechanistic insights from cryo-electron tomography

The paper uses cryo-electron tomography to study actin filament organization during clathrin-mediated endocytosis, revealing how actin dynamics generate pulling forces for vesicle formation.

Biomembranes undergo complex, non-axisymmetric deformations governed by Kirchhoff-Love kinematics and revealed by a three dimensional computational framework

The paper presents a 3D computational framework for modeling biomembrane deformations using Kirchhoff-Love kinematics, demonstrating its ability to capture non-axisymmetric deformations and symmetry-breaking behaviors.

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

A mechanical model reveals that non-axisymmetric buckling lowers the energy barrier associated with membrane neck constriction

This study uses a mechanical model to show that non-axisymmetric buckling reduces the energy barrier for membrane neck constriction compared to symmetric necks.

Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

The paper uses a multiscale model to show that actin networks enable clathrin-mediated endocytosis by self-organizing and adapting to membrane tension through Arp2/3 complexes and bent filaments.

DLITE uses cell-cell interface movement to better infer cell-cell tensions

DLITE infers cell-cell tensions from interface movement, showing better correlation with ground truth than prior methods and detecting tension changes during mitosis.

The role of traction in membrane curvature generation

This paper demonstrates how membrane curvature can be used to infer local tractions and shows that different membrane deformations correspond to distinct traction distributions.