Author

R. Zechner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

P. Hofer· 2 shared A. K. Simon· 1 shared B. I. Wieser· 1 shared C. Edwards· 1 shared C. F. Rodriguez Gamez· 1 shared E. Johnson· 1 shared F. C. Richter· 1 shared F. Powrie· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

P. Hofer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unmasking Crucial Residues in Adipose Triglyceride Lipase (ATGL) for Co-Activation with Comparative Gene Identification-58 (CGI-58)

N. Kulminskaya, C. F. Rodriguez Gamez, P. Hofer, I. K. Cerk, N. Dubey, R. Viertlmayr, T. Sagmeister, T. Pavkov-Keller, R. Zechner, M. Oberer

This study identifies key residues in ATGL critical for co-activation with CGI-58 using mutagenesis and AlphaFold modeling.

bioRxiv · Jun 26, 2023Biochemistry

Adipocyte lipolysis protects the host against Trypanosoma brucei infection

H. Machado, P. Hofer, R. Zechner, L. M. Figueiredo

This study shows that adipocyte lipolysis during Trypanosoma brucei infection reduces parasite burden and fat mass, acting as a host-protective mechanism.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

F. C. Richter, M. Friedrich, N. Kampschulte, M. Pohin, G. Alsaleh, I. Guschina, S. K. Wideman, E. Johnson, M. Borsa, K. Piletic, P. Hahn, H. S. Schipper, C. Edwards, R. Zechner, N. H. Schebb, , A. K. Simon

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

bioRxiv · Oct 25, 2021Immunology

Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven lipogenesis

B. I. Wieser, P. Pena de la Sancha, S. Schauer, H. Reicher, W. Sattler, R. Breinbauer, M. Schweiger, P. J. Espenshade, R. Zechner, G. Hoefler, P. W. Vesely

This study shows that ATGL-derived unsaturated FAs suppress SREBP-1c activation, linking lipolysis and lipogenesis through an ATGL/SREBP-1c axis.

bioRxiv · Nov 2, 2020 · PreprintBiochemistry