C. Edwards

Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy

The paper shows that mTORC1 signaling hypersensitivity to leucine drives an onco-circuit in T cell malignancy, and a low leucine diet is therapeutic without impairing T cell immunity.

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis

This study develops methods to culture human and animal airway explants for at least 14 days, preserving tissue architecture and enabling study of health, disease, and viral infection.

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

This study shows STING activation promotes Tr1 cell development during malaria by enhancing IFNB gene transcription and modulates this pathway with ruxolitinib.

Scanning ion-conductance microscopy for studying β-amyloid aggregate formation on living cell surface

This study uses scanning ion-conductance microscopy to investigate how β-amyloid aggregates affect the mechanical properties of living cells.

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

Syndecan-1 facilitates breast cancer metastasis to the brain

This study shows that syndecan-1 promotes breast cancer metastasis to the brain by enhancing cell migration across the blood-brain barrier and altering cytokine secretion.

Intracellular mechanisms of fungal space searching in microenvironments

This study investigates how fungal hyphae navigate microenvironments using live-cell imaging of Neurospora crassa, revealing how the Spitzenkorper-microtubule system adapts to obstacles.

Evolution of Portulacineae marked by gene tree conflict and gene family expansion associated with adaptation to harsh environments

This study reconstructs the phylogeny of Portulacineae and examines molecular evolution correlates with adaptation to harsh environments, identifying gene duplications and expansions linked to stress responses.