S. Beesam

Cooperative cis-interactions between ectodomains of TCRαβ CD3 subunits enable mechanotransduction

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

In situ cell-surface conformation of the TCR-CD3 signaling complex

The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.