Author

M. Krogsgaard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Natarajan· 3 shared C. Ge· 2 shared C. Zhu· 2 shared P. Cong· 2 shared S. Beesam· 2 shared B. Liu· 1 shared D. Grazette· 1 shared H. W. Shin· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

A. Natarajan

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Author profile →

3 papers

Recent·Most cited

Cooperative cis-interactions between ectodomains of TCRαβ CD3 subunits enable mechanotransduction

P. Cong, A. Natarajan, Z. Yuan, C. Ge, S. Travaglino, R. Dezhkam, S. Beesam, X. Li, D. Grazette, M. Krogsgaard, C. Zhu

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

bioRxiv · Apr 14, 2022 · PreprintImmunology

In situ cell-surface conformation of the TCR-CD3 signaling complex

M. Krogsgaard, A. Natarajan, W. Wang, M. B. Flores, T. Li, H. W. Shin, S. Beesam, T. Cardozo

The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.

bioRxiv · Feb 7, 2022 · PreprintImmunology

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

H.-K. Choi, P. Cong, C. Ge, A. Natarajan, B. Liu, Y. Zhang, K. Li, M. N. Rushdi, W. Chen, J. Lou, M. Krogsgaard, C. Zhu

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

bioRxiv · Jan 17, 2022Biophysics