C. Ge

Tumor microenvironments impair T cell receptor affinity and function

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

Subtyping evaluation of Salmonella Enteritidis using SNP and core genome MLST with nanopore reads

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

Cooperative cis-interactions between ectodomains of TCRαβ CD3 subunits enable mechanotransduction

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

An integrated approach to protein discovery and detection from complex biofluids

This paper develops a mass spectrometry method to detect microproteins in vaginal lavages and identifies cystatin A as a potential biomarker for early ovarian cancer detection.

Local conjugation of auxin by the GH3 amido synthetases is required for normaldevelopment of roots and flowers in Arabidopsis

This study shows that GH3 amido synthetases conjugate auxin, and their deletion causes developmental defects in Arabidopsis roots and flowers.

Reference genome and resequencing of 305 accessions provide insights into spinach evolution, domestication and genetic basis of agronomic traits

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

An amiRNA screen uncovers redundant CBF & ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Evaluation of Nanopore sequencing technology to differentiate Salmonella serotypes and serotype variants with the same or closely related antigenic formulae

This study evaluates Nanopore sequencing for differentiating Salmonella serotypes and variants with similar antigenic formulas using SNP analysis and prophage prediction.

PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana

This study identifies PIEZO as a mechanosensitive ion channel in Arabidopsis roots, showing its role in mechanotransduction and mechanical stress response.

iRhom2 serves as a facilitator in obesity by enhancing adipose inflammation and insulin resistance

This study identifies iRhom2 as a key regulator that promotes obesity-associated metabolic disorder by enhancing adipose inflammation and insulin resistance.