Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome
H.-K. Choi, S. Travaglino, M. Munchhalfen…·C. Zhu
This study shows that CD40-CD40L interactions form catch bonds that enhance B cell signaling and antibody class-switch, and mutations in CD40L disrupt this mechanism, causing X-linked Hyper IgM syndrome.