S. George

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias.

This paper shows that TAK-981 activates NK cells against AML by inducing IFN-I secretion, enhancing their cytotoxicity and cytokine production.

COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination and Drug Susceptibility Prediction

This study evaluates direct-from-sputum whole-genome sequencing for tuberculosis diagnosis, lineage determination, and drug susceptibility prediction using different sequencing technologies.

Complex regulatory role of DNA methylation in caste- and age-specific expression of a termite.

This study investigates DNA methylation's role in caste- and age-specific gene expression in termite queens, finding significant methylation changes and links to alternative splicing in aging and fertility.

Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19

This study compares T cell responses in children and adults with mild/asymptomatic COVID-19, finding differences in T cell diversity and memory formation.

Conformational diversity of CDR region during affinity maturation determines the affinity and stability of Sars-Cov-1 VHH-72 nanobody

Mud, microbes, and macrofauna: seasonal dynamics of the iron biogeochemical cycle in an intertidal mudflat

This study examines seasonal changes in the iron biogeochemical cycle in an intertidal mudflat, showing how temperature, microbial communities, and macrofauna influence iron dynamics.

Race specific differences in DNA damage repair dysregulation in breast cancer and association with outcome

The paper identifies race-specific DNA damage repair (DDR) gene dysregulation patterns in African American (AA) ER+ breast cancer patients and links them to poorer survival outcomes.

A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors

The paper identifies CX3CR1 expression on circulating CD8+ T cells as a biomarker predicting response to immune checkpoint inhibitor therapy in NSCLC patients.

DNA Thermo-Protection Facilitates Whole Genome Sequencing of Mycobacteria Direct from Clinical Samples by the Nanopore Platform

This paper develops a thermo-protection buffer to enable direct whole genome sequencing of Mycobacteria from clinical samples using Nanopore technology, achieving high coverage at low bacterial concentrations.

Evolutionary route of resistant genes in Staphylococcus aureus

This study identifies the evolutionary routes of resistant genes in S. aureus through phylogenomic analysis, revealing frequent lateral gene transfer from non-Staphylococcus sources.

MinION Nanopore Sequencing of Multiple Displacement Amplified Mycobacteria DNA Direct from Sputum

This study evaluates the effectiveness of multiple displacement amplification followed by MinION sequencing for detecting Mycobacteria DNA in sputum samples.

An algorithm for automated, noninvasive detection of cortical spreading depolarizations based on EEG simulations

This paper introduces an algorithm for detecting cortical spreading depolarizations from EEG signals using simulations and validates it on synthetic data.

Comparison of two commercial ELISA kits for detection of rubella specific IgM and IgG antibodies

This study compares two ELISA kits for detecting rubella-specific IgM and IgG antibodies, finding good qualitative agreement and suggesting Euroimmun as a viable alternative.