S. C. Greenway

The paper identifies altered glutamine and lactate metabolism in DCMA patient fibroblasts as a predictor of cardiac dysfunction severity.

This study uses iPSC-derived cardiomyocytes from DCMA patients to show reversible mitochondrial fragmentation and OPA1 isoform imbalance, suggesting SS-31 as a potential therapy.

This study shows that inhibiting retinoic acid signaling early in differentiation rapidly generates ventricular-like cardiomyocytes from human iPSCs with higher MLC2V expression.

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

This study shows vancomycin reduces MMF-induced GI toxicity by inhibiting gut bacterial β-glucuronidase activity, preventing MPA conversion from its glucuronidated form.